2012-12-09T19:04:54-08:00
Resource:Database of Interacting Proteins
DIP
curated
http://dip.doe-mbi.ucla.edu/
Catalogs experimentally determined interactions between proteins. It combines information from a variety of sources to create a single, consistent set of protein-protein interactions. The data stored within the DIP database were curated, both, manually by expert curators and also automatically using computational approaches that utilize the the knowledge about the protein-protein interaction networks extracted from the most reliable, core subset of the DIP data.
Because the reliability of experimental evidence varies widely, methods of quality assessment have been developed and utilized to identify the most reliable subset of the interactions. This CORE set can be used as a reference when evaluating the reliability of high-throughput protein-protein interaction data sets, for development of prediction methods, as well as in the studies of the properties of protein interaction networks. Tools are available to analyze, visualize and integrate user's own experimental data with the information about protein-protein interactions available in the DIP database.
The DIP (Database of Interacting Proteins) database lists protein pairs that are known to interact with each other. By interact we mean that two amino acid chains were experimentally identified to bind to each other. The database lists such pairs to aid those studying a particular protein-protein interaction but also those investigating entire regulatory and signaling pathways as well as those studying the organization and complexity of the protein interaction network at the cellular level.<br />
The DIP database is composed of nodes and edges:
* DIP Nodes (proteins) Each protein participating in a DIP interaction is identified by a unique identifier of the form DIP:nnnN and cross-references to, at least, one of the major protein databases - PIR, SWISSPROT and/or GENBANK In addition, some basic information about each protein, such as name, function, subcellular localization and cross-references to other biological databases is stored locally (if available) in case the cross-referenced databases are not accessible.
* DIP Edges (interactions) The information about each DIP interaction is identified by a unique identifier of the form DIP:nnnE that provides access to information such as the region involved in the interaction, the dissociation constant and the experimental methods used to identify and characterize the interaction.<br />
Registration is required to gain access to most of the DIP features. Registration is free to the members of the academic community. Trial accounts for the commercial users are also available.<br />
nif-0000-00569
Resource:Database of Interacting Proteins
2012-12-04T00:00:00
Resource
Resource:APID: Agile Protein Interaction DataAnalyzer
RelatedTo
Resource
National Institute of General Medical Sciences
Supporting Agency
SuperCategory
ModifiedDate
Label
Yeast
Sequence
Receptor
Protein receptor
Protein-protein interaction
Protein ligand
Protein interaction
Protein
Network
Ligand-receptor complex
Ligand
Human
Helicobacter pylori
Cellular networks
Blast
Keywords
University of California at Los Angeles; California; USA
Is part of
Id
Data storage repository
Data analysis service
Database
Has role
Definition
DefiningCitation
CurationStatus
Abbrev