2013-07-18T06:53:40-07:00
Resource:Cortical Circuits and Dendritic Spines
uncurated
http://www.columbia.edu/cu/biology/faculty/yuste/
<br />
The goal of This laboratory is to understand the function of the cortical microcircuit. It attempts to reverse-engineer the cortical microcircuit using brain slices from mouse neocortex as the experimental preparation.<br />
The techniques applied are electrophysiology, anatomy, and a variety of optical methods, including infrared-DIC, voltage- and ion-sensitive dye imaging with confocal, two-photon and second harmonic microscopy. This lab also uses laser uncaging, biolistics, electroporation, electron microscopy and numerical simulations, and makes extensive use of genetically modified mouse strains.<br />
The focus is on two major questions:<br />
(1) What is the function of dendritic spines?<br />
(2) What are the multicellular patterns of activity under spontaneous or evoked activation of the circuit?<br />
Sponsors: This lab is affiliated and supported by:<br />
- Howard Hughes Medical Institute<br />
- Columbia Biological Sciences<br />
- Frontiers in Neural Circuits<br />
- Kavli Institute for Brain Science<br />
- Department of Neuroscience<br />
- Columbia Neuroscience<br />
- Columbia BioImaging Igert Program<br />
- Cajal Blubrain Project<br />
- Biophysics and Biophysical Chemistry Program<br />
From the laboratory of Rafael Yuste<br />
nif-0000-10407
Resource:Cortical Circuits and Dendritic Spines
2013-06-20T00:00:00
Resource
Rafael Yuste's Lab
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Voltage sensitive dye
Uncaging
Two-photon
Second harmonic
Optical method
Neocortex
Multicellular
Mouse
Microscopy
Microcircuit
Ion sensitive dye
Infrared-dic
Dendtritic spine
Cortical
Confocal
Circuit
Biolistics
Anatomy
Engineer
Electrophysiology
Electrophoration
Electron microscopic imaging assay
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Columbia University; New York; USA
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