2011-09-20T20:15:51-07:00
Resource:Ancillary Domains Associated With Human and Mouse Proteases
curated
http://degradome.uniovi.es/domains.html
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The aim of this website is to provide an updated version of human, chimpanzee, mouse, and rat proteases and protease inhibitors, as well as as the growing number of hereditary diseases caused by mutations in protease genes. Analysis of the human and mouse genomes has allowed us to annotate 570 human, 570 chimpanzee, 656 mouse, and 646 rat protease genes. Proteases are classified in five different classes according to their mechanism of catalysis. Follow the links on the left to browse each protease class.<br />
Proteases are a diverse and important group of enzymes representing >2% of the human, chimpanzee, mouse and rat genomes. This group of enzymes is implicated in numerous physiological processes. The importance of proteases is illustrated by the existence of 84 different hereditary diseases due to mutations in protease genes. Furthermore, proteases have been implicated in multiple human pathologies, including vascular diseases, rheumatoid arthritis, neurodegenerative processes, and cancer. During the last ten years, our laboratory has identified and characterized more than 60 human protease genes.<br />
Due to the importance of proteolytic enzymes in human physiology and pathology, we have recently introduced the concept of Degradome, as the complete repertoire of proteases expressed by a tissue or organism. Thanks to the recent completion of the human, chimpanzee, mouse, and rat genome sequencing projects, these researchers were able to analyze and compare for the first time the complete protease repertoire in those mammalian organisms, as well as the complement of protease inhibitor genes. This website is a repository of this information.<br />
nif-0000-25547
Resource:Ancillary Domains Associated With Human and Mouse Proteases
2011-05-18T00:00:00
Ancillary Domains
Resource
Synonym
ModifiedDate
Label
Vascular
Sequence
Rheumatoid
Repository
Rat
Protease
Process
Physiological
Pathology
Organism
Neurodegenerative
Mutation
Mouse
Mechanism
Mammalian
Inhibitor
Human
Hereditary
Genome
Disease
Chimpanzee
Catalysis
Cancer
Arthritis
Gene
Enzyme
Keywords
Universidad de Oviedo; Oviedo; Spain
Is part of
Id
Data storage repository
Laboratory portal
Web accessible database
Has role
Definition
DefiningCitation
CurationStatus