2013-05-01T10:08:07-07:00
Resource:Roadmap Epigenomics Project
Roadmap Epigenomics Project
Division of Program Coordination
Planning
and Strategic Initiatives
National Institutes of Health
Bethesda
Maryland 20892
curated
http://roadmapepigenomics.org/
A public resource of human epigenomic data from experimental pipelines built around next-generation sequencing technologies to map DNA methylation, histone modifications, chromatin accessibility and small RNA transcripts in stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease. The Consortium expects to deliver a collection of normal epigenomes that will provide a framework or reference for comparison and integration within a broad array of future studies. The Consortium also aims to close the gap between data generation and its public dissemination by rapid release of raw sequence data, profiles of epigenomics features and higher-level integrated maps to the scientific community. The Consortium is also committed to the development, standardization and dissemination of protocols, reagents and analytical tools to enable the research community to utilize, integrate and expand upon this body of data.
Epigenetics is an emerging frontier of science that involves the study of changes in the regulation of gene activity and expression that are not dependent on gene sequence. For purposes of this program, epigenetics refers to both heritable changes in gene activity and expression (in the progeny of cells or of individuals) and also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable. While epigenetics refers to the study of single genes or sets of genes, epigenomics refers to more global analyses of epigenetic changes across the entire genome.
The overall hypothesis of the NIH Roadmap Epigenomics Program is that the origins of health and susceptibility to disease are, in part, the result of epigentic regulation of the genetic blueprint. Specifically, epigenetic mechanisms that control stem cell differentiation and organogensis contribute to the biological response to endogenous and exogenous forms of stimuli that result in disease.
The Roadmap Epigenomics Program proposes to: (1) create an international committee; (2) develop standardized platforms, procedures, and reagents for epigenomics research; (3) conduct demonstration projects to evaluate how epigenomes change; (4) develop new technologies for single cell epigenomic analysis and in vivo imaging of epigenetic activity; and (5) create a public data resource to accelerate the application of epigenomics approaches.Transforming biomedical research in the following ways:* Develop comprehensive reference epigenome maps* Develop new technologies for comprehensive epigenomic analysesA series of five interrelated initiatives are currently being developed under this program.
nlx_151644
Resource:Roadmap Epigenomics Project
2012-12-05T00:00:00
22690667, 20944595, 20944597
Resource
NIH Roadmap Epigenomics Project
Common Fund Epigenomics Program
NIH Common Fund Epigenomics Program
Common Fund Epigenomics
NIH Common Fund Epigenomics
Common Fund Roadmap Epigenomics Program
NIH Roadmap Epigenomics Program
Epigenomics Program
Resource:NCBI Epigenomics
Resource:VizHub
Resource:Spark
Resource:VizHub
Resource:Human Epigenome Atlas
Resource:Human Epigenome Browser
RelatedTo
Resource
Synonym
SuperCategory
Human
Species
PMID
ModifiedDate
Label
Histone
Methylation
DNA
RNA transcript
Chromatin
Histone modification
DNA methylation
Substantia nigra
Mid frontal lobe
Inferior temporal lobe
Hippocampus
Cingulate gyrus
Anterior caudate
Angular gyrus
Skin
Induced pluripotent stem cell
Adrenal
Kidney
Placenta
Spleen
Thymus
Hematopoietic stem cell
Fat
Genitourinary
Gastrointestinal
Connective
Muscle
Breast
RNA
ChIP-Seq
Methylome
Epigenome
Cell
Adult
Fetus
Embryonic stem cell
Brain
Gastrointestinal tract
Heart
Lung
Blood
Tissue
Primary cell
Stem cell
Genomics
Gene regulation
Genetic variation
Genome
Epigenomics
Keywords
NIH Common Fund
Is part of
Id
Standard specification
Data analysis service
Experimental protocol
Database
Topical portal
Has role
File:Roadmap Epigenomics Project.PNG
ExampleImage
Definition
DefiningCitation
CurationStatus
Address
Abbrev