2014-12-28T00:10:52-08:00
Resource:OncoTrack
OncoTrack
Type: Industry, Government <br />
Participant countries: E.U. <br />
Country started: E.U. <br />
Number of partners: 18 <br />
Start date: 2011 <br />
Project duration: 5 years
curated
http://www.oncotrack.eu/
An international consortium to develop and assess novel approaches to identify and characterize biological markers for colon cancer that will deepen the understanding of the variable make-up of tumors and how this affects the way patients respond to treatment. They will use cutting edge laboratory-based genome sequencing techniques coupled to novel computer modelling approaches to study both the biological heterogeneity of colon cancers (i.e. patient to patient variability) as well as tumor variation within the patient – for example, by comparing primary tumors with metastases. This five year project brings together top scientists from European academic institutions offering a wide range of expertise, and partners them with pharmaceutical companies.
The project is based on the premise that this genetic and epigenetic information, combined with a description of the molecular pathology of the tumor, will allow OncoTrack to generate a more accurate in-silico model of the cancer cell. This will facilitate the identification of predictive markers that can be used to guide the optimal therapy strategy – at the level of the individual patient - and will also provide on-going prognostic guidance for the clinician.
This project will not only advance understanding of the fundamental biology of colon cancers but will provide the means and approach for the identification of previously undetected biomarkers – not only in the cancer under study, but potentially also in other solid cancers and, in doing so, open the door for personalized management of the oncology patient.
nlx_158037
Resource:OncoTrack
2014-10-28T00:00:00
Resource
Onco Track
OncoTrack - Methods for systematic next generation oncology biomarker development
Resource:eTRIKS
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Resource:GenomeWeb
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Resource:European Federation of Pharmaceutical Industries and Associations
Resource:Innovative Medicines Initiative
Supporting Agency
SuperCategory
Human
Species
Tumor
Colon cancer
Related disease
International Prevention Research Institute
Resource:GABO:mi
Resource:Experimental Pharmacology and Oncology Berlin-Buch
Resource:Alacris Theranostics
Vall d'Hebron Institute of Oncology; Barcelona; Spain
Stockholm University; Stockholm; Sweden
Uppsala University; Uppsala; Sweden
University College London; London; United Kingdom
Dresden University of Technology; Dresden; Germany
Paris-Sud University; Paris; France
Medical University of Graz; Graz; Austria
Charite - Universitatsmedizin Berlin; Berlin; Germany
Resource:Eli Lilly and Company
Resource:Pfizer
Resource:Merck KGaA
Resource:Janssen Pharmaceuticals Inc.
Resource:Roche
Resource:Boehringer Ingelheim
Resource:AstraZeneca
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Resource:Consortia-pedia
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Tumor variability
Patient variability
In-silico model
Systems biology
Clinical
Genomics
Treatment
Cancer
Colon
Cancer cell
Model
Pathology
Epigenetic
Genetic
Computer modelling
Genome sequencing
Basic science
Diagnosis
Biomarker
Oncology
Keywords
Max Planck Institute for Molecular Genetics; Berlin; Germany
Resource:Bayer HealthCare Pharmaceuticals
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Consortium
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File:OncoTrack.PNG
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