2012-03-29T17:54:25-07:00
Resource:Estonian Genome Center
EGCUT, EGC
curated
http://www.geenivaramu.ee/en/
The Estonian Biobank is the population-based biobank of the EGCUT. The project is conducted in accordance with the Estonian Genes Research Act and all participants have signed a broad informed consent form (www.biobank.ee <http://www.biobank.ee/> and Metspalu 2004, Drug Dev. Res.). As of December 2011, the biobank contains 51,515 participants (gene donors). The database of genotypic, phenotypic, health and genealogical information represents about 5% of Estonia’s adult population, and is the largest cohort ever gathered in Estonia. The age, sex and geographical distribution of this cohort reflect the structure of the adult population in Estonia.
The database enables to conduct research in order to find links between genes, environmental factors, lifestyles and complex diseases or other traits. Active use of the biobank has started and although the first users are researchers all over the world with hundreds of different projects currently underway, industry is also interested. At the international level, the EGCUT will join the BBMRI follow-up program (ERIC) and through this channel provide service (biobanking, genotyping, sequencing and data analysis) for the centers in Europe who need it. Currently, the first follow-up study is underway and the molecular information of the cohort will be increased. For example, we have over 12 000 DNA samples analyzed by high density genotyping arrays and over 10 000 plasma samples analyzed by NMR scans, over 1000 individuals with RNA expression arrays, 2000 individuals with clinical laboratory analysis (over 40 tests) and over 60 full genomes are under deep sequencing.
The infrastructure of the EGCUT includes a laboratory for DNA genotyping and next generation sequencing all based on Illumina platforms (HiScanSQ, HiSeq2000 and robotics), an IT unit (databases) with required computing power and storage space (1.2PB), data analysis team (bioinformatics and statistical genetics) and last but not least, a patient recruitment unit (health records, lifestyle and environmental information and biological samples – DNA, plasma and WBC from all 51515 gene donors). This is all located on 1000m2 in a brand new laboratory building, Riia str 23, Tartu, Estonia.
nlx_45748
Resource:Estonian Genome Center
2012-03-06T00:00:00
Estonian Genome Center University of Tartu
Estonian Biobank
Resource
Synonym
Resource:Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)
Human
RelatedTo
ModifiedDate
Label
Genetic
Demographic
Lifestyle
Blood
Plasma
White blood cell
DNA
Clinical data
Epidemiology
Genomics
Disease
Environmental factor
Gene
WBC
Data analysis
Sequencing
Genotyping
Biobanking
Population-based study
Population-based studies
Biomedicine
Keywords
European Biobank
University of Tartu; Tartu; Estonia
Is part of
Id
Data analysis service
Database
Biomaterial supply resource
Has role
File:Estonian Genome Center.PNG
ExampleImage
Definition
DefiningCitation
CurationStatus
Address:Tartu, Estonia Phone: +372 7 440 200 Fax: +372 7 440 221
Comment
Abbrev